A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Joshi, V. G.
- Wound Healing Effects of Mussaenda frondosa Extracts on Second Degree Superficial Burned Rat
Authors
1 Dept of Pharmacognosy, Maratha Mandal's College of Pharmacy, Belgaum, 560010, Karnataka, IN
2 Dept of Pharmaceutics, Government College of Pharmacy, Bengaluru, IN
3 Dept of Pharmacology, Maratha Mandal's College of Pharmacy, Belgaum, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 3 (2012), Pagination: 163-168Abstract
Background: Finding more efficient agents with fewer side effects for treatment of burns has always been a concern for researchers. Silver sulfadiazine (SSD), apparently due to its antimicrobial effect, is still one of the most common prescribed agents. Previous studies suggested that leaves of Mussaenda frondosa Linn (MF) has shown antimicrobial and antiinflammatory activities. This study investigates the healing effect of MF extract in comparison with SSD in second degree burn wounds.
Methods: Adult albino rats of weight around 150-200 gm were divided into 4 groups. Standard second degree burn wounds were induced on the back of their necks. One group was treated with SSD; two groups were treated with alcoholic extract (AE) cream of MF at concentrations of 10% (AE10) and aqueous extract (AQE) cream of MF at concentrations of 10% (AQE10) and the control group which received no treatment. The duration of treatment was 16 days.
Results: This study revealed that AE and SSD noticeably improved reepithelization, lipid peroxde, and collagen bundle synthesis and had a noticeable effect on TBAR compared with the control group.
Keywords
Mussaenda frondosa Linn, Silver Sulfadiazine, Burn Rat.References
- Medline Plus. "Burns". Retrieved 2010-09-22
- WebMD (January 7, 2009). "Burns-Topic Overview". Firstaid andemergencies. Retrieved 2010-09-22
- Total Burn Care, 3rd Edition, Edited by David Herndon, Saunders, 2007.
- Radek KA, Matthies AM, Burns AL, Herinrich SA, Kovacs EJ, Dipietro LA (2005). Acute ethanol exposure impair angiogenesis and the proliferative phase of wound healing. Am. J. Physiol., 289(3): H1084-90.
- Singer AJ, Clark RA (1999). Cutaneus wound healing. N. Engl. J. Med., 341(10): 738-46.
- Senger DR, Ledbetter SR, Claffey KP, Papadopoulos-Sergiou A, Peruzzi CA, Detar M (1996). Stimulation of endothelial growth factor through cooperative mechanism involving the alphabeta3 integrin, osteopontin, and thrombin. Am. J. Pathol., 149(1): 293-305.
- Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N (1989). Vascular endothelial growth factor is a secreted angiogenic mitogen. Sci., 246(4935): 1306-09.
- Spyridopoulos I, Brogi E, Kearney M, Sullivan AB, Cetrulo C, Isner JM, Losordo DW (1997). Vascular endothelial growth factor inhibits endothelial cell aptosis induced by tumor necrosis factor-alpha: balance between growth and death signals. J. Mol. Cell Cardiol., 29(5): 1321-30.
- Wilgus TA, Matthies AM, Radek KA, Dovi JV, Burns AL, Shankar K, DiPietro LA (2005). Novel function for vascular endothelial growth factor receptor-1 on epidermal keratinocytes. Am. J. Pathol., 167(5): 1257-66.
- J. L. Gupta, L. K. Makhija, and S. P. Bajaj. National programme for prevention of burn injuries. Indian J Plast Surg. 2010 September; 43(Suppl): S6-S10.
- http://www.springerlink.com/content/m627322 p 542 97782/
- Wealth of India A Dictionary of Raw material and Industrial products Vol. III, New Delhi, Publication and Information Directorate , CSIR 1952:168.
- Basu, B.D., Kirtikar. K. Indian Medicinal Plants. 2nd ed. International book distributors, Dehradun.1987; (2):1270 -71.
- Jain S.K. 1991, Dictionary of Indian folk medicine and Ethnobotany, Deep publication.:83.
- Ashok Seth. The herbs of Ayurveda. Volume III: 788.
- Dr. Nadkarni K. M. "Indian material medica" Bombay popular prakashan; 827.
- Meenakshisundaram sreepriya, Geetha Bali http://lib. Bioinfo.pl/medi: 67120 Mol cell Biochem. 2006 Mar, 284 (1- 2): 49-55 .
- Khare C. P. Indian Medicinal Plants: 427.
- Dr. Mukherji PK, Quality Control Of Herbal Drugs, 1st edition, Business Horizons, Pharmaceutical Publishers, New Delhi, 2002: 379-82.
- Dr. Kokate CK, Practical Pharmacognosy, Vallabh Prakashan, 1994: 144.
- Ghosh MN Fundamentals of Experimental Pharmacology. 2005:1-6.
- Organization for economic co-operation and development, revised draft guidelines423.OECD guideline for the testing of chemicals. Revised Document. October 2000.
- Bairy KL, Somayaji SN, Rao CM. An experimental model to produce partial thickness burn wound. Ind J Exp Biol.1997:35(1):70-2.
- Uduppa KN. Advances in research in Indian Medicine. A dissertation submitted to Banaras Hindu University, Varanasi.1970:270-303.
- Sharma SP, Aithal KS, Srinivasan KK. Fitoterpia.1990:61:263.
- Okhawa H, Ohishi N, Yagi K. Annal Biochem . 1979:95:351- 55.
- Tripathi YB, Sharma M. Indian J Biochem. Biophys.1998:35:313-16.
- Patil PA, Kulkarni DR. Antiproliferative agents in healing of incision wounds in rats.Ind J Exp Biol.1985:23:149-50.
- Annie Shirwaikar,Radhika Shenoy, AL Udupa, SL Udupa, Somashekar Shetty Wound healing property of ethanolic extract of leaves of Hyptis suaveoles with supportive role of antioxidant enzymes Ind J Exp Biology 2003:vol 41:238-41.
- Madden JW, Morton D, Peacock EE. Contraction of experimental wounds in inhibiting wound contraction by using a topical smooth muscle antagonist.Surgery.1974:76(1):8-15.
- Getie, M, T .Gebre-Mariam, R . Rietz and R. H. Neubert. 2002. Evaluation of the release profiles of flavonoids from topical formulations of the crude extract of the leaves of Dodonaea viscose (Sapindaceae). Pharmazie, 57(5): 320-22.
- Arti Parihar, Mordhwaj S. Parihar, Stephen Milner, Satyanarayan Bhat. Oxidative stress and anti-oxidative mobilization in burn injury. Burns Volume 34, Issue 1, Feb. 2008: 6-17
- Getie M, Gebre M, Reitz R, Neubert RH. Evaluation of the release profiles of flavonoids from topical formulations of the crude extracts of the leaves of Dodonea viscose Pharmazie.2002; 57:320-22.
- Tsuchiya H, et.al. Comparative study on antibacterial activity of phytochemical 7-34. flavones against methicillin resistant staphylococcus aureus.J.Ethnopharmacol.1996; 50:2.
- The Monetary Approach to the Balance of Payments and Exchange Rate: Empirical Evidence Relating Specifically to India
Authors
Source
Artha Vijnana: Journal of The Gokhale Institute of Politics and Economics, Vol 32, No 3-4 (1990), Pagination: 270-280Abstract
An Outline of the Monetary Approach
The theory of balance of payments, which is basically concerned with the analysis of pOlicies for maintaining balance-of-payments equilibrium, is one of the most controversial subjects in what is today known as International Macroeconomics. The rediscovery of the monetary approach to the balance of payments by Mundell (1968) and Johnson (1972) has led to a series of fresh discussions on this subject. This is evident from the growing number of research papers in academic journals of international stature.
- Evaluation of Wound Healing Activity of Isolated Compound Quercetin and Alcoholic Extract of Leaves of Mussaenda frondosa Linn
Authors
1 Dept of Pharmacognosy, Maratha Mandal’s College of Pharmacy, Belgaum-560010, Karnataka, IN
2 Dept. of Pharmaceutics, Government College of Pharmacy, Bengaluru, IN
3 Dept. of Pharmacology, Maratha Mandal’s College of Pharmacy, Belgaum, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 6 (2011), Pagination: 266-271Abstract
Since the time immemorial, our traditional system of medicine and folklore claiming that medicinal plants as a whole or their parts are being used in all types of diseases. Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for wounds. Alcoholic extract of leaves of Mussaenda frondosa Linn. (Rubiaceae) and its isolated compound quercetin were evaluated for wound healing activity by using different types of wound healing models such as excision wound, incision wound and dead space wound. The results were obtained in terms of wound contraction, epithelialization time and tensile strength. All results were significant for different parameters in wound healing activity in quercetin and alcoholic extract treated animals compared with control groups. The isolated compound quercetin was confirmed by preliminary phytochemical investigation, IR, NMR and Mass spectroscopic methods.
Keywords
Mussaenda frondosa Linn, Wound Healing Activity, Alcoholic Extract, Quercetin.- Hepatoprotective and Antioxidant Potential of Extracts from Whole Plant of Solanum surattense Burm
Authors
1 Dept of Pharmacognosy, Maratha Mandal’s College of Pharmacy, Belgaum.560010. Karnataka, IN
2 Maratha Mandal's College of Pharmacy, Belgaum, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 1 (2011), Pagination: 17-21Abstract
Objectives: Alcoholic and aqueous extracts of Solanum surattense Burm were investigated for their Hepatoprotective and Antioxidant potentials against Liver injury induced by CCl4 in rats.
Methods: The liver damage was induced in male albino rats (150-200g) by administering CCl4 (2ml/kg) for 7 days and extent of damage was studied by assessing biochemical and Antioxidant level in liver parameters such as aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin, lipid peroxidase (LPO) with a reduction of total protein, superoxide dismutase (SOD), catalase, and glutathione Stransferase (GST) in experimental animals. Histopathological changes of liver sample were compared with respective control.
Results: Treatment of rats with alcoholic and aqueous plant extract (200mg/kg) for 7 days resulted in significant (P<0.001) reduction in serum marker enzymes and antioxidant levels to near normal against CCl4-treated rats. The protection effect was found to be comparable with Liv52 treated group.
Conclusion: The alcoholic extracts of Solanum surattense Burm have protected liver from CCl4 damage. The probable mechanism may be due to Steroid and Tannins known for their Antioxidant activity may potentially confer protection against oxidative stress induced liver injury.
Keywords
Hepatoprotective, Antioxidant, Solanum surattense Burm, Carbon Tetrachloride, Biochemical Parameters, Histopathology.- Preliminary Pharmacognostical and Phytochemical Studies of Leaves of Hemigraphis colorata
Authors
1 Sarada Vilas College of Pharmacy, Mysore- 570004, Karnataka, IN
2 Sarada Vilas College of Pharmacy, Krishnamurthypuram, Mysore-570004, Karnataka, IN
3 Marata Mandal College of Pharmacy, Belgaum, Karnataka, IN
4 Genba Sopanrao Moze College of Pharmacy, Pune, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 1 (2010), Pagination: 15-17Abstract
The aim of this research was to develop the pharmacognostical parameters and phytochemical screening alongwith histological studies and quantitative microscopy of the leaf powder of Hemigraphis colorata.
The dried leaves of Hemigraphis colorata (Family: Acanthaceae) were subjected to standardization by following pharmacognostical and phytochemical screening methods. Methanolic extract was subjected to thin layer chromatography (TLC) to find out various phytoconstituents.
Microscopic study showed the presence of Cuticle, covering trichome, single layered thick walled epidermis, palisade cells, transfusion tissue, spongy cells, vascular bundle and chlorenchyma. Phytochemical screening reported the presence of alkaloids, tannins, proteins; steroids and sterols were present in Methanolic extract. TLC showed two different Rf values (0.86 and 0.36) with different nature of their residues.